Time: 15:00, December 9, 2021 

Speaker: Dr. Haifeng Hou, Fudan University Cancer Institute, China

Host: Prof. Yuxiang Weng, CAS Key Lab of Soft Matter and Biological Physics

Abstract:

In eukaryotic organisms, gene expression is mediated by combined action of transcription factors and transcription machineries in the context of chromatin, which provides framework for differential gene expression and cell fate determination during development. Regulatory proteins, RNA and DNA template all play a role in determining how, where, and when genes are expressed. It’s yet unclear how these components interact to regulate gene expression. In this talk, I will discuss our recent progress on structural snapshots of human Pol III transcription cycle regulation and assembly of Pol II preinitiation complex.

Brief CV of Dr. Shuyi Liu:

Dr. Hou received his B.S. degree from Beijing Institute of Technology in 2003 and Ph.D. degree from Institute of High Energy Physics, CAS, in 2008. From 2008 to 2017, he studied structural biology in Institute of High Energy Physics, CAS as an Assistant professor and Associate professor. From 2017, he moved to Fudan University Shanghai Cancer Center to continue his research in gene transcription field. Combining biochemical, biophysical methods, Dr.  Hou’s research program aims to understand eukaryotic transcription at cellular, molecular, and atomic levels. His research will deepen the molecular understanding of transcription cycle regulation. So far, his representative academic achievements have been published in journals such as Science、 Nature、Cell Research、Nature Communications、Current Opinion in Structural Biology.